Population
Isolated rabbit hearts (Langendorff preparation) and isolated fresh cardiomyocytes
Comparison
Remote ischaemic preconditioning in vivo, or… vs Control (no rIPC or control plasma/dialysate)
Design
Preclinical
Authors
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Extends preclinical evidence for opioid-dependent humoral mediators in rIPC; leaves open translation to human cardioprotection trials.
Transient limb ischaemia releases a transferable, low-molecular-mass (<15 kDa) hydrophobic circulating factor that protects the myocardium against ischaemia/reperfusion injury via opioid receptor activation.
Shimizu et al. (2009) studied this question.
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