Why the study?
Ischemic heart disease causes irreversible cardiomyocyte damage, but the mammalian heart's neonatal regenerative ability disappears with age, with non-coding RNAs playing a pivotal role.
Design
Review
Authors
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ncRNA strategies for post-MI regeneration remain preclinical; leaves open clinical translation pending prospective trials.
Non-coding RNAs represent a promising therapeutic target for promoting cardiomyocyte proliferation and cardiac regeneration following ischemic injury.
Qin et al. (2022) studied this question.
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