Population
Offspring of pregnant rats made diabetic with 50 mg/kg streptozotocin
Comparison
Moderate maternal hyperglycemia and severe… vs Offspring of non-diabetic control rats
Design
Preclinical
Follow-up
Postnatal day 21
Authors
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Maternal diabetes severity may influence offspring cardiomyopathy risk; leaves open human translation and MAPK-targeted interventions.
The severity of maternal hyperglycemia determines the phenotype of transient cardiomyopathy in offspring, with resolution associated with activation of MAPK and apoptotic pathways.
Reinking et al. (2009) studied this question.
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