Population
24 Zucker rats (12 obese, 12 age-matched lean) at 5 to 6 months of age
Comparison
Obese phenotype (obese Zucker rats) vs Age-matched lean Zucker rats
Design
Preclinical
Authors
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Does not inform clinical obesity management; leaves open mitochondrial apoptosis as a driver of human heart failure.
The cardiac mitochondrial-dependent apoptotic pathway is more activated in obese Zucker rats, providing a possible mechanism for the development of heart failure in obesity.
Lu et al. (2007) studied this question.