Population
In vitro model using polymorphonuclear leukocytes (PMNs) and human umbilical vein endothelial cells (HUVECs)
Comparison
Coculture of PMNs and HUVECs, or addition of… vs HUVECs grown separately
Design
Preclinical
Follow-up
2-16 h
Authors
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May implicate PMNs in microvascular injury via novel MMP-2 activation; hypothesis-generating and requires in vivo confirmation.
PMNs release a soluble factor that activates endothelial cell MMP-2 through a novel mechanism independent of cell-cell contact, potentially contributing to microvascular injury.
Schwartz et al. (1998) studied this question.
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