An oxidized analog of α‐human atrial natriuretic polypeptide is a selective agonist for the atrial‐natriuretic‐polypeptide clearance receptor which lacks a guanylate cyclase

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Population

Bovine pulmonary aortic endothelial cell line, Hela cells from human cervical carcinoma, and in vivo models

Comparison

MetSO-alpha-hANP vs alpha-human atrial natriuretic polypeptide

Design

Preclinical

Authors

Discussion

May facilitate selective ANP-R2 probing in preclinical models; leaves open any human therapeutic role.

Population

Bovine pulmonary aortic endothelial cell line (CPAE cells), Hela cells from human cervical carcinoma, and in vivo models

Intervention

MetSO-alpha-hANP (oxidized analog of alpha-human atrial natriuretic polypeptide)

Comparator

alpha-human atrial natriuretic polypeptide (alpha-hANP)

Outcome

Receptor binding affinity (ANP-R1 vs ANP-R2) and guanylate cyclase stimulationsurrogate

MetSO-alpha-hANP acts as a selective agonist for the ANP-R2 clearance receptor, demonstrating distinct receptor selectivity compared to alpha-hANP.

Koyama et al. (1992) studied this question.

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