Why the study?
Does transplantation of embryonic stem cells or their conditioned medium improve cardiac function and reduce adverse pathological mechanisms in mice with doxorubicin-induced cardiomyopathy?
Population
C57Bl/6 mice with doxorubicin-induced cardiomyopathy (cumulative dose of DOX 12 mg/kg body weight, IP)
Comparison
Transplanted embryonic stem cells or their… vs Cell culture medium
Design
Preclinical
Follow-up
Two weeks post-DIC
Authors
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May attenuate remodeling in doxorubicin mouse models; leaves open clinical translation of ES cell therapy.
Does transplantation of embryonic stem cells or their conditioned medium improve cardiac function and reduce adverse pathological mechanisms in mice with doxorubicin-induced cardiomyopathy?
Transplantation of embryonic stem cells or their conditioned medium reduces apoptosis and fibrosis and enhances cardiac regeneration in a mouse model of doxorubicin-induced cardiomyopathy.
Singla et al. (2012) studied this question.
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