Deconstructing endothelial dysfunction: soluble guanylyl cyclase oxidation and the NO resistance syndrome

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Structured PICO

Population

Animal models of endothelial dysfunction and human blood vessels from patients with diabetes

Intervention

BAY 58-2667

Outcome

Activation of oxidized and heme-free soluble guanylyl cyclase (sGC) and vasodilatory potencysurrogate

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Highlights the potential of targeting oxidized, heme-free sGC with BAY 58-2667 to overcome NO resistance in endothelial dysfunction.

Mark T. Gladwin (2006) studied this question.

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