What question did this study set out to answer?

To test whether slow, controlled breathing acutely enhances cardiovagal baroreflex sensitivity in young healthy individuals when evaluated using gold-standard pharmacological testing.

July 17, 2009Journal of Applied Physiology

Respiratory modulation of cardiovagal baroreflex sensitivity

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Why the study?

Does slow controlled breathing acutely enhance cardiovagal baroreflex function in young healthy volunteers?

Key Points

To test whether slow, controlled breathing acutely enhances cardiovagal baroreflex sensitivity in young healthy individuals when evaluated using gold-standard pharmacological testing.
Assessed 30 young healthy volunteers (N=30) during fast breathing (0.25 Hz) and slow deep breathing (0.10 Hz).
Measured cardiovagal baroreflex sensitivity across a wide blood pressure range using the classical pharmacological modified Oxford method.
Evaluated spontaneous cardiovagal baroreflex sensitivity concurrently using the spectral alpha-index and the sequence method.
Slow breathing at 0.10 Hz increased the alpha-index by 8.1 ± 14 ms/mmHg (P < 0.01) and spontaneous up-sequence baroreflex sensitivity by 10 ± 11 ms/mmHg (P < 0.01) compared with 0.25 Hz breathing.
Spontaneous down-sequence baroreflex sensitivity and baroreflex sensitivity quantified by the pharmacological modified Oxford method showed no significant change during slow breathing.

Structured PICO

Does slow controlled breathing acutely enhance cardiovagal baroreflex function in young healthy volunteers?

Population

30 young healthy volunteers

Intervention

Slow controlled breathing (0.10 Hz)

Comparator

Fast breathing (0.25 Hz)

Outcome

Cardiovagal baroreflex sensitivity (BRS) assessed using the classical pharmacological modified Oxford methodsurrogate

Slow breathing does not acutely augment arterial baroreflex function when assessed by experimentally driven baroreceptor stimulation, challenging previous assumptions based on spontaneous BRS measures.

Discussion

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Implication

Slow breathing does not enhance baroreflex sensitivity by modified Oxford method; leaves open validity of spontaneous BRS changes in healthy adults.

Cite This Study

Tzeng et al. (2009) studied this question.

synapsesocial.com/papers/6a85428cff13e6e4e743db77 https://doi.org/10.1152/japplphysiol.00548.2009

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Implication

Slow breathing does not enhance baroreflex sensitivity by modified Oxford method; leaves open validity of spontaneous BRS changes in healthy adults.

Respiratory modulation of cardiovagal baroreflex sensitivity

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Respiratory modulation of cardiovagal baroreflex sensitivity

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

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