May 1, 1988Journal of NeuroscienceOpen Access

Cardiovascular function is altered by picomole injections of glutamate into rat medulla

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Population

Urethane-anesthetized, artificially ventilated rats

Comparison

Injection of L-glutamate into the nucleus… vs Concurrent injection of glutamic acid diethyl…

Design

Preclinical

Authors

DND. NelsonNorthwestern University HCHL CohenNorthwestern University JFJack L. FeldmanUniversity of California, Los Angeles

Discussion

Member takes

Implication

Animal data preclude clinical translation; extends mapping of NTS subregions in rodent cardiovascular control.

Structured PICO

Population

Urethane-anesthetized, artificially ventilated rats

Intervention

Injection of L-glutamate (as little as 200 fmol in 200 pl) into the nucleus tractus solitarius (NTS)

Comparator

Concurrent injection of glutamic acid diethyl ester and DL-2-amino-4-phosphonobutyrate, or lidocaine; or blockade of parasympathetic and sympathetic neural outflow

Outcome

Changes in arterial pressure and heart ratesurrogate

Microinjections of L-glutamate reveal spatial heterogeneity in the brain-stem circuitry of the nucleus tractus solitarius controlling cardiovascular function in rats.

Cite This Study

Nelson et al. (1988) studied this question.

synapsesocial.com/papers/6a8543eee3de713998f2479d https://doi.org/10.1523/jneurosci.08-05-01684.1988

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Bookmark

Cardiovascular function is altered by picomole injections of glutamate into rat medulla

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiovascular function is altered by picomole injections of glutamate into rat medulla

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider