Why the study?
As COVID-19 vaccination became widespread, side effects not initially detected in trials emerged, prompting a review of adverse cardiovascular events associated with vaccination.
Does COVID-19 vaccination cause adverse cardiovascular events?
Does COVID-19 vaccination cause adverse cardiovascular events?
COVID-19 vaccination is associated with rare cardiovascular complications, most notably myocarditis and myopericarditis, which disproportionately affect young male patients.
Case reports of post-vaccination cardiovascular events remain hypothesis-generating; larger prospective studies are needed to quantify incidence and causality.
As vaccination against COVID-19 became more widespread, side-effects that were not initially detected during clinical trials became more prominent. The aim of this systematic review is to discuss reports of adverse cardiovascular events associated with COVID-19 vaccination. Databases were searched from inception up to August 2022 to identify case reports and case series reporting on patients with cardiovascular disease after COVID-19 vaccination. This study assessed 150 published cases. Of these, 109 were case reports and 41 were case series. The majority of patients were male (n=302, 86.6%), with a mean age of 27.6 ± 16.7 years. Of the included patients, 268 (76.6%) had myocarditis, 50 (14.6%) had myopericarditis, 8 (2.3%) had pericarditis, and only 4 (1.1%) had stress-induced cardiomyopathy. Moreover, 30 (8.6%) and 11 (3.1%) were diagnosed with arrhythmia and ischaemic heart disease, respectively. Ultimately, cardiovascular complications after COVID-19 vaccination include myocarditis, myopericarditis, ischaemic heart disease and arrhythmia. The young population, especially young male patients, could be more vulnerable to myocarditis.
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Khaity et al. (2023) studied this question.
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