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April 1, 2004Diabetes CareOpen Access

Type 2 Diabetes and Intravenous Thrombolysis Outcome in the Setting of ST Elevation Myocardial Infarction

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Why the study?

Does type 2 diabetes reduce the effectiveness of intravenous thrombolysis and worsen long-term prognosis in patients with ST elevation myocardial infarction?

Population

726 consecutive subjects with ST elevation myocardial infarction who received intravenous thrombolysis in…

Comparison

Type 2 diabetes (exposure) vs Nondiabetic subjects

Design

Cohort

Follow-up

3.5 years

Authors

MZMichael N. ZairisTzaneion General HospitalALAnastassios G. LyrasTzaneion General HospitalSMStamatis S. MakrygiannisHygeia Hospital

Discussion

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Overview

Diabetes may impair ST recovery after thrombolysis in STEMI; hypothesis-generating for diabetes-specific reperfusion strategies.

Structured PICO

Does type 2 diabetes reduce the effectiveness of intravenous thrombolysis and worsen long-term prognosis in patients with ST elevation myocardial infarction?

P
Population
726 consecutive subjects with ST elevation myocardial infarction (STEMI) who received intravenous thrombolysis in the first 6 hours from index pain (214 with type 2 diabetes).
I
Intervention
Type 2 diabetes (exposure)
C
Comparator
Nondiabetic subjects
O
Outcome
Acute intravenous thrombolysis effectiveness (sustained ≥ 50% ST recovery) and long-term prognosis (cardiac death) at 3.5 yearshard clinical

Type 2 diabetes is a strong predictor of acute intravenous thrombolysis failure and is associated with worse long-term prognosis in patients with STEMI.

Cite This Study

Zairis et al. (2004) studied this question.

synapsesocial.com/papers/6a8545574b2893ddcbc6b695https://doi.org/10.2337/diacare.27.4.967
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Also Consider

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  1. 1Diabetes mellitus is a strong negative prognostic factor in patients with myocardial infarction treated with thrombolytic therapy2000 · 21 citations
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  3. 3Mechanisms Determining Course and Outcome of Diabetic Patients Who Have Had Acute Myocardial Infarction1997 · 306 citations
  4. 4Continuous 12-lead ST-segment recovery analysis in the TAMI 7 study. Performance of a noninvasive method for real-time detection of failed myocardial reperfusion.1993 · 167 citations
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