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June 1, 1999Avian PathologyOpen Access

Development and composition of lymphoid lesions in the spleens of Marek's disease virus-infected chickens: Association with virus spread and the pathogenesis of Marek's disease

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Population

White Leghorn chickens of line 72 (Marek's disease susceptible) and line 61 (Marek's disease resistant)

Comparison

Marek's disease virus (MDV) infection vs Comparison between MD susceptible and MD…

Design

Preclinical

Follow-up

8+ days post-inoculation

Authors

SBSusan J. BaigentThe Pirbright InstituteTDT.F. DavisonThe Pirbright Institute

Discussion

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Implication

Delineates lymphocyte changes favoring MDV spread in susceptible chickens; hypothesis-generating for resistance mechanisms in poultry.

Structured PICO

P
Population
White Leghorn chickens of line 72 (Marek's disease susceptible) and line 61 (Marek's disease resistant)
I
Intervention
Marek's disease virus (MDV) infection
C
Comparator
Comparison between MD susceptible (line 72) and MD resistant (line 61) chickens
O
Outcome
Changes in lymphocyte distribution in spleens assessed by immunocytochemistrysurrogate

MDV infection in susceptible chickens leads to specific lymphoid lesions and T cell responses that favor the tumor stage of Marek's disease.

Cite This Study

Baigent et al. (1999) studied this question.

synapsesocial.com/papers/6a85455bff13e6e4e743dd87https://doi.org/10.1080/03079459994786
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Differential susceptibility to Marek's disease is associated with differences in number, but not phenotype or location, of pp38+ lymphocytes.1998 · 68 citations