Why the study?
RA is associated with skeletal muscle weakness and increased CVD risk, but therapeutic exercise is often avoided due to fear of worsening RA pathology.
Does endurance exercise improve joint, cardiac, and skeletal muscle function in a K/BxN mouse model of inflammatory arthritis?
Does endurance exercise improve joint, cardiac, and skeletal muscle function in a K/BxN mouse model of inflammatory arthritis?
Endurance exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis, suggesting potential therapeutic benefits for patients with rheumatoid arthritis.
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Supports exercise investigation in inflammatory arthritis models; leaves open translation to human rheumatoid arthritis.
RA, even when controlled, is associated with skeletal muscle weakness and greater risk of cardiovascular disease (CVD). Using exercise as a therapeutic against, the progression of RA is often avoided due to fear of worsening RA pathology. We introduce the K/BxN mouse as an RA model to study both myocardial and skeletal muscle dysfunction. We show that endurance exercise can improve joint, cardiac, and skeletal muscle function in K/BxN mice, suggesting exercise may be beneficial for patients with RA.
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Huffman et al. (2021) studied this question.
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