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December 1, 2020CJC OpenOpen Access

The State of the Heart Biopsy: A Clinical Review

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Why the study?

Endomyocardial biopsy is an invaluable and underused diagnostic tool for myocardial disease, with evolving techniques and indications across cardiac allograft rejection, inflammatory cardiomyopathy, and infiltrative cardiomyopathy.

Design

Clinical review

Authors

OKOmid KiamaneshTwitter (United States)MTMustafa TomaProvidence Health Care

Discussion

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Overview

Supports continued EMB role in allograft surveillance and select myocarditis; extends safety data while leaving non-invasive strategy trials open.

Structured PICO

P
Population
Patients with myocardial disease, specifically those undergoing surveillance for cardiac allograft rejection or diagnosis of inflammatory and infiltrative cardiomyopathies
I
Intervention
Endomyocardial biopsy (EMB)

Endomyocardial biopsy remains a crucial diagnostic tool for cardiac allograft rejection and specific inflammatory cardiomyopathies, despite being replaced as a first-line test for infiltrative diseases.

Cite This Study

Kiamanesh et al. (2020) studied this question.

synapsesocial.com/papers/6a85462264694fc428d97d65https://doi.org/10.1016/j.cjco.2020.11.017
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Evaluation of Left and Right Ventricular Endomyocardial Biopsy2010 · 437 citations
  2. 2Management of Myocarditis-Related Cardiomyopathy in Adults2019 · 285 citations
  3. 3Immunosuppressive Therapy Improves Both Short- and Long-Term Prognosis in Patients With Virus-Negative Nonfulminant Inflammatory Cardiomyopathy2018 · 105 citations
  4. 4Recognition and Initial Management of Fulminant Myocarditis2020 · 627 citations
  5. 5Pathogenic RBM20 -Variants Are Associated With a Severe Disease Expression in Male Patients With Dilated Cardiomyopathy2019 · 96 citations