Why the study?
Myocardial interstitial fibrosis is linked to cardiovascular disease and adverse prognosis, prompting investigation into the biological pathways underlying fibrosis in the human heart.
What genetic loci and biological pathways are associated with myocardial interstitial fibrosis as measured by native T1 time on cardiac MRI?
Population
41,505 UK Biobank participants who underwent cardiac magnetic resonance imaging
Design
Genome-wide association study using a machine learning model
Authors
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Provides genetic loci for T1-derived fibrosis; leaves open causal mechanisms and clinical translation.
What genetic loci and biological pathways are associated with myocardial interstitial fibrosis as measured by native T1 time on cardiac MRI?
Large-scale machine learning quantification of myocardial T1 time identified 11 genetic loci associated with myocardial interstitial fibrosis, revealing new biologically relevant pathways.
Nauffal et al. (2023) studied this question.