What question did this study set out to answer?

To determine 20-year survival rates and evaluate key prognostic factors among individuals diagnosed with thin invasive melanomas (≤ 1.00 mm).

March 13, 2012Journal of Clinical OncologyOpen Access

Population-Based 20-Year Survival Among People Diagnosed With Thin Melanomas in Queensland, Australia

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To determine 20-year survival rates and evaluate key prognostic factors among individuals diagnosed with thin invasive melanomas (≤ 1.00 mm).
Extracted cancer registry records for individuals diagnosed with a single thin invasive melanoma (≤ 1.00 mm) from 1982 to 2006 matched to national death registry data through December 31, 2007 (N=26,736; Queensland, Australia).
Calculated melanoma-specific survival rates and evaluated subgroup prognostic variations using multivariate Cox proportional hazards models.
Melanoma-specific 20-year survival across the cohort of thin melanoma cases was 96%.
The strongest determinants of mortality were tumor thickness ≥ 0.75 mm (adjusted HR, 4.33; 95% CI, 2.8 to 6.8 compared with < 0.25 mm) and age older than 65 years at diagnosis (HR, 2.8; 95% CI, 1.8 to 4.5 compared with < 25 years).
Independent increases in melanoma-specific death risk were observed for male sex, scalp or neck tumor sites, tumor invasion across the entire papillary dermis, and acral lentiginous or nodular histologic subtypes.

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Implication

Population-based cohort study reveals a 96% twenty-year survival rate in thin invasive melanoma, highlighting increased long-term mortality risk among older patients and thicker lesions.

Cite This Study

Green et al. (2012) studied this question.

synapsesocial.com/papers/6a85468be1eabc68e29294e7 https://doi.org/10.1200/jco.2011.38.8561

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Implication

Population-based cohort study reveals a 96% twenty-year survival rate in thin invasive melanoma, highlighting increased long-term mortality risk among older patients and thicker lesions.

Population-Based 20-Year Survival Among People Diagnosed With Thin Melanomas in Queensland, Australia

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Discussion

Implication

Cite This Study

Population-Based 20-Year Survival Among People Diagnosed With Thin Melanomas in Queensland, Australia

Key Points

Discussion

Implication

Cite This Study

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