What question did this study set out to answer?

To identify and map the genetic elements responsible for nonrandom X chromosome inactivation associated with the X chromosome controlling element (Xce) in mice.

August 12, 2012GeneticsOpen Access

Nonrandom X Chromosome Inactivation Is Influenced by Multiple Regions on the Murine X Chromosome

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Authors

JTJoanne L. ThorvaldsenUniversity of Pennsylvania CKChristopher KrappDuke University HWHuntington F. WillardGeisinger Medical Center

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Implication

Genetic mapping reveals multiple regions flanking Xist/Tsix influence skewed X inactivation in hybrid mice, indicating a multigenic controlling element.

Key Points

To identify and map the genetic elements responsible for nonrandom X chromosome inactivation associated with the X chromosome controlling element (Xce) in mice.
Intercrossed 129S1/SvImJ mice (carrying Xce-a) and Mus musculus castaneus EiJ mice (carrying Xce-c) to create recombinant lines with single or double breakpoints near or within the Xce candidate interval.
Mated 129S1/SvImJ females with recombinant males and quantified the X chromosome inactivation ratio in female progeny via allele-specific expression assays of X-linked genes.
Identified distinct regulatory regions located both proximal and distal to the Xist/Tsix locus that bias the choice of X chromosome inactivation.
Demonstrated that the genetic effect traditionally attributed to the single Xce locus is driven by multiple elements across the murine X chromosome.

Cite This Study

Thorvaldsen et al. (2012) studied this question.

synapsesocial.com/papers/6a85470edf831772a6d6a1f6 https://doi.org/10.1534/genetics.112.144477

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Implication

Genetic mapping reveals multiple regions flanking Xist/Tsix influence skewed X inactivation in hybrid mice, indicating a multigenic controlling element.

Nonrandom X Chromosome Inactivation Is Influenced by Multiple Regions on the Murine X Chromosome

Discussion

Member takes

Implication

Key Points

Cite This Study

Nonrandom X Chromosome Inactivation Is Influenced by Multiple Regions on the Murine X Chromosome

Discussion

Member takes

Implication

Key Points

Cite This Study

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