Population
Theiler's murine encephalomyelitis virus (DA strain) / murine model
Comparison
Generation of an infectious DA cDNA clone… vs Wild-type virus
Design
Preclinical
Authors
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Confirms functional DA cDNA clone; leaves open mapping of demyelination loci via interstrain recombinants.
The generation of an infectious DA cDNA clone provides a critical reagent for producing interstrain recombinant viruses to study genetic loci responsible for viral biological activities.
Roos et al. (1989) studied this question.
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