May 1, 1985Journal of VirologyOpen Access

Shutoff of host translation by encephalomyocarditis virus infection does not involve cleavage of the eucaryotic initiation factor 4F polypeptide that accompanies poliovirus infection

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Population

Host cells (model not explicitly stated in abstract)

Comparison

Encephalomyocarditis virus infection vs Poliovirus infection

Design

Preclinical

Authors

JMJ MosenkisWashington University in St. Louis SDSusan Daniels-McQueenWashington University in St. Louis SJS JanovecWashington University in St. Louis

Discussion

Member takes

Implication

Distinguishes EMCV shutoff from poliovirus in animal models; leaves open relevance to human cells or other picornaviruses.

Structured PICO

Population

Host cells (model not explicitly stated in abstract)

Intervention

Encephalomyocarditis virus infection

Comparator

Poliovirus infection

Outcome

Proteolytic cleavage of eucaryotic initiation factor 4F polypeptidesurrogate

Encephalomyocarditis virus shuts off host translation through a different mechanism than poliovirus, as it does not involve cleavage of the eucaryotic initiation factor 4F polypeptide.

Cite This Study

Mosenkis et al. (1985) studied this question.

synapsesocial.com/papers/6a854823895c7e29f4c6bb9b https://doi.org/10.1128/jvi.54.2.643-645.1985

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