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August 1, 1996Journal of General Virology

Equine rhinovirus serotypes 1 and 2: relationship to each other and to aphthoviruses and cardioviruses

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Population

Equine rhinovirus (ERV) serotypes 1 and 2 genomes

Design

Preclinical

Authors

GWGordana WutzResearch Institute of Molecular PathologyHAHerbert AuerMedical University of ViennaNNNorbert NowotnyMohammed Bin Rashid University of Medicine and Health Sciences

Discussion

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Implication

May position ERV-1 as a model for FMDV; leaves open its experimental utility pending functional validation.

Key Points

  • Determine the genetic organization and taxonomic classification of equine rhinovirus serotypes 1 and 2 in relation to aphthoviruses and cardioviruses.
  • Cloned and sequenced cDNA from ERV-1 and ERV-2 genomes between the poly(C) and poly(A) tracts.
  • Compared genomic architecture and deduced viral protein sequences to foot-and-mouth disease virus (FMDV) and encephalomyocarditis virus (EMCV).
  • ERV-1 shares genomic organization and derived protein sequence identity most closely with FMDV.
  • ERV-2 exhibits marked sequence divergence from ERV-1, displaying greater protein homology with EMCV than with FMDV.
  • ERV-1 is placed alongside FMDV in the aphthovirus genus, demonstrating its viability as a surrogate model for studying FMDV biology.

Structured PICO

P
Population
Equine rhinovirus (ERV) serotypes 1 and 2 genomes
I
Intervention
cDNA cloning and sequencing
O
Outcome
Genomic architecture and protein sequence identity compared to foot-and-mouth disease virus (FMDV) and encephalomyocarditis virus (EMCV)

ERV-1 is closely related to FMDV and belongs to the aphthovirus genus, suggesting it could serve as a model system for studying FMDV biology.

Cite This Study

Wutz et al. (1996) studied this question.

synapsesocial.com/papers/6a8548a6f76e40547ac2b41fhttps://doi.org/10.1099/0022-1317-77-8-1719
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evolutionary relationships within the human rhinovirus genus: comparison of serotypes 89, 2, and 14.1987 · 82 citations
  2. 2A distinct picornavirus group identified by sequence analysis.1992 · 278 citations
  3. 3Antibodies to the vitronectin receptor (integrin alpha V beta 3) inhibit binding and infection of foot-and-mouth disease virus to cultured cells1995 · 301 citations
  4. 4Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4 gamma1994 · 193 citations
  5. 5RGD sequence of foot-and-mouth disease virus isessential for infecting cells via the natural receptor but can be bypassed by anantibody-dependent enhancement pathway.1994 · 254 citations