Myocardial Toxicity from Carbon Monoxide Poisoning

Article1 December 1967Myocardial Toxicity from Carbon Monoxide PoisoningROBERT F. ANDERSON, M.D., DANIEL C. ALLENSWORTH, M.D., WILLIAM J. DEGROOT, M.D.ROBERT F. ANDERSON, M.D., DANIEL C. ALLENSWORTH, M.D., WILLIAM J. DEGROOT, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-6-1172 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe pathology of the heart in carbon monoxide poisoning was described by Klebs (1) in 1865. He found diffuse punctiform hemorrhages and necrotic foci throughout the heart, particularly in the septum and papillary muscles. Since then sporadic case descriptions and electrocardiographic abnormalities have been reported (2-5). This paper presents our experience with carbon monoxide poisoning at The University of Texas Medical Branch Hospitals. Cases will be described consisting of two families, emphasizing the individual susceptibility to carbon monoxide and the seriousness of the myocardial lesion.CASE REPORTSA family of four was discovered unconscious in their home on January 12,...References1. KLEBS E: Über die Wirkung des kohlenoxyds auf den thierische organisms. Virchow. Arch. Path. Anat. 32: 450, 1865. CrossrefGoogle Scholar2. MIDDLETONASHBYCLARK GDDWF: Delayed and long-lasting electrocardiographic changes in carbon monoxide poisoning. Lancet 1: 12, 1961. CrossrefMedlineGoogle Scholar3. COSBYBERGERON RSM: Electrocardiographic changes in carbon monoxide poisoning. Amer. J. Cardiol. 11: 93, 1963. CrossrefMedlineGoogle Scholar4. HAYESHALL JMGV: The myocardial toxicity of carbon monoxide. Med. J. Aust. 1: 865, 1964. CrossrefMedlineGoogle Scholar5. EHRICHBELLETLEWEZ WESFH: Cardiac changes from carbon monoxide poisoning. Amer. J. Med. Sci. 208: 511, 1944. CrossrefGoogle Scholar6. 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JAMA 86: 455, 1926. Google Scholar14. TAKAHASHI K: Cardiac disturbances due to CO poisoning in experimental animals. I. Electrocardiographic changes due to CO poisoning and those under the influence of fluid infusion. Tohoku J. Exp. Med. 74: 211, 1961. CrossrefMedlineGoogle Scholar15. ROUGHTONDARLING FJRC: The effect of carbon monoxide on the oxyhemoglobin dissociation curve. Amer. J. Physiol. 141: 17, 1944. CrossrefGoogle Scholar16. ROUGHTONROOT FJWS: The fate of carbon monoxide in the body from mild carbon monoxide poisoning in man. Amer. J. Physiol. 145: 239, 1938. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT F. ANDERSON, M.D.; DANIEL C. ALLENSWORTH, M.D.; WILLIAM J. DEGROOT, M.D.Affiliations: Galveston, TexasFrom the Department of Internal Medicine, The University of Texas Medical Branch, Galvesto, Tex.This study was supported in part by grant 5T02 HE 5098-13, National Institutes of Health, Bethesda, Md.This work was completed during Dr. Anderson's tenure as a Fellow under training grant fellowship 5T1 HE 5587-04, National Institutes of Health.Requests for reprints should be addressed to Robert F. Anderson, M.D., Austin Diagnostic Clinic, 801 W. 34th St., Austin, Tex. 78705. 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