April 1, 1983Canadian Journal of Physiology and Pharmacology
Selective activation of the adrenal medulla during acute bilateral carotid occlusion and its modulation by α-adrenergic receptors in the rat
Population
Chloralose anesthetized rats
Comparison
1-min bilateral carotid occlusion with or… vs Basal conditions and intact animals
Design
Preclinical
Authors
Discussion
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Implication
Alpha2 modulation of baroreflex epinephrine release remains hypothesis-generating in rats; leaves open any clinical relevance to human hypertension or baroreflex therapies.
Structured PICO
P
Population
Chloralose anesthetized rats (including intact, vagotomized, chemically sympathectomized, and bilaterally adrenalectomized models)
I
Intervention
1-min bilateral carotid occlusion (CO) with or without pharmacological modulation (Yohimbine, Clonidine, phenoxybenzamine)
C
Comparator
Basal conditions and intact (non-vagotomized) animals
O
Outcome
Mean arterial pressure (MAP) and circulating norepinephrine (NE) and epinephrine (E) levelssurrogate
Baroreflex activation of the adrenal medulla induced by carotid occlusion in rats may be modulated in vivo via alpha 2-adrenergic receptors localized on chromaffin cells.
Cite This Study
Bouvier et al. (1983) studied this question.