This preclinical study suggests that the brain stem, specifically basilar blood flow and a vasoregulatory center in the pons, plays a role in the pathogenesis of hypertension.
Preclinical data implicate brainstem vasoregulation in hypertension; leaves open translation to human disease.
(1) There is a vasoregulatory center in the basal portion of the pons besides in the medulla oblongata. The experimental evidences to support this concept were briefly described. (2) In dogs, normal responsiveness of basilar blood flow to intravenously administered vasoactive substances (norepinephrine, epinephrine and synthetic angiotensin II) requires normal function of the kidney. The responsiveness of basilar blood flow differed from that of internal carotid blood flow in dogs with renal hypertension and with nephrectomy, although the latter responded like in normal dogs. The altered responsiveness of basilar blood flow was restored towards normal when medullorenal extract was given. (3) Ligation of the basilar artery produced hypertension in dogs. (4) The significance of these findings as replated to pathogenesis of hypertension was discussed.
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S Katsuki (1966) studied this question.
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