January 1, 1978Clinical Science
The Role of Vasopressin in Blood Pressure Control and in Experimental Hypertension
Why the study?
Does vasopressin play a significant role in blood pressure control and the pathogenesis of one-kidney Goldblatt hypertension in conscious dogs?
Population
Conscious dogs
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Questions vasopressin's role in canine Goldblatt hypertension; leaves open its relevance in other models or humans.
Structured PICO
Does vasopressin play a significant role in blood pressure control and the pathogenesis of one-kidney Goldblatt hypertension in conscious dogs?
P
Population
Conscious dogs (including normal dogs, dogs with pharmacological autonomic blockade, and unilaterally-nephrectomized dogs)
I
Intervention
Infusion of synthetic arginine vasopressin, mild non-hypotensive haemorrhage, or renal artery constriction
O
Outcome
Changes in heart rate, mean arterial blood pressure, plasma vasopressin concentration, and plasma renin activitysurrogate
Vasopressin may play a role in normal cardiovascular homeostatic responses, but its role in the pathogenesis of one-kidney Goldblatt hypertension is unlikely to be significant.
Cite This Study
Pullan et al. (1978) studied this question.