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November 1, 1993Journal of Applied Physiology

Contribution of vasopressin to blood pressure regulation during hypovolemic hypotension in humans

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Why the study?

Does intravenous vasopressin V1 receptor antagonist alter blood pressure regulation during hypovolemic hypotension in normal subjects?

Population

12 normal subjects

Comparison

Intravenous administration of vasopressin V1… vs Lower body negative pressure-induced hypotension…

Design

Other

Authors

AHA T HirschBrigham and Women's HospitalJMJoseph A. MajzoubBoston Children's HospitalCRChao-lai RenTianjin Hospital

Discussion

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Implication

Vasopressin V1 blockade does not worsen LBNP hypotension in healthy subjects; challenges animal data and leaves open its role in clinical hypovolemia.

Structured PICO

Does intravenous vasopressin V1 receptor antagonist alter blood pressure regulation during hypovolemic hypotension in normal subjects?

P
Population
12 normal subjects
I
Intervention
Intravenous administration of vasopressin V1 receptor antagonist during lower body negative pressure (LBNP)-induced hypotension
C
Comparator
Lower body negative pressure (LBNP)-induced hypotension before drug administration (within-subject comparison)
O
Outcome
Systolic blood pressuresurrogate

In contrast to animal studies, vasopressin does not appear to contribute to the maintenance of blood pressure during hypovolemic hypotension in humans.

Cite This Study

Hirsch et al. (1993) studied this question.

synapsesocial.com/papers/6a7d53f8a7839e36ac1cd565https://doi.org/10.1152/jappl.1993.75.5.1984
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of vasopressin on the circulation and its baroreflex control in healthy men.1986 · 37 citations
  2. 2Evidence and quantification of the vasopressin arterial pressure control system in the dog.1980 · 153 citations
  3. 3Cardiac and arterial baroreceptor influences in release of vasopressin and renin during hemorrhage1987 · 69 citations
  4. 4Autonomic, hormonal, and local circulatory effects of hemorrhage in conscious rabbits1990 · 38 citations
  5. 5Relationship of Cardiac Chamber Volume to Baroreflex Activity in Normal Humans1987 · 21 citations