Biosynthese der Cytochalasane. Teil II Die Grundbausteine von Cytochalasin D

A number of potential 14 C‐ and 3 H‐labelled precursors were fed to growing cultures of Zygosporium masonii after the rate of formation of cytochalasin D had been measured. By chemical degradation of [ 14 C]‐ and [ 3 H, 14 C]‐cytochalasin D the distribution of the radioactivity originating from incorporated [4′‐3H, U‐ 14 C]‐ L ‐phenylalanine and [CH 3 ‐ 14 C]‐ L ‐methionine was determinated. The results demonstrate that the building blocks of cytochalasin D are 1 unit of pheylalanine, 3 units of methionine and acetate units.