Why the study?
Does vecuronium compared to pancuronium increase the incidence of bradycardia in patients undergoing anaesthesia for elective surgery?
Does vecuronium compared to pancuronium increase the incidence of bradycardia in patients undergoing anaesthesia for elective surgery?
Vecuronium is associated with a higher incidence of bradycardia compared to pancuronium during elective surgery, which can be mitigated by the administration of glycopyrronium.
Answers are grounded in this paper and cite their sources.
Vecuronium may increase bradycardia risk versus pancuronium; leaves open confirmation in randomized trials before practice change.
One hundred and twenty patients undergoing anaesthesia for elective surgery received either pancuronium or vecuronium for muscle relaxation. Within each of these two groups, half were given glycopyrronium and the remainder an inert placebo. The incidence of bradycardia or bradydysrhythmias was higher in the group having vecuronium compared with those given pancuronium. Glycopyrronium afforded protection against undesirable vagal activity.
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Cozanitis et al. (1987) studied this question.
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