Why the study?
Does vecuronium affect heart rate or mean arterial pressure in healthy patients undergoing elective surgery under halothane-nitrous oxide anaesthesia?
Does vecuronium affect heart rate or mean arterial pressure in healthy patients undergoing elective surgery under halothane-nitrous oxide anaesthesia?
Vecuronium does not have a clinically significant impact on heart rate or mean arterial pressure during halothane-nitrous oxide anesthesia in healthy surgical patients.
Supports vecuronium when hemodynamic stability matters; confirms cardiovascular neutrality under halothane-nitrous oxide anesthesia.
In a double-blind, placebo-controlled, prospective randomized trial in 70 otherwise healthy patients undergoing elective surgery of the thyroid gland, the breast, the inguinal canal or the lower limbs, we studied the cardiovascular effects of vecuronium during halothane-nitrous oxide anaesthesia. Vecuronium was found to have no clinically significant influence on heart rate or mean arterial pressure, before or during surgery. Bradycardia was a rare event under the special conditions of the study design.
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Kristensen et al. (1989) studied this question.
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