May 1, 2006Diabetes Care
Antihypertensive Therapy and the Risk of New-Onset Diabetes
Why the study?
Do different classes of antihypertensive medications affect the risk of new-onset diabetes?
Population
Patients receiving antihypertensive therapy
Design
Review
Authors
Discussion
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Member takes
Implication
May warrant preferring ACEIs/ARBs/CCBs over high-dose thiazides or beta-blockers in diabetes-prone patients; leaves open need for dedicated outcome trials.
Structured PICO
Do different classes of antihypertensive medications affect the risk of new-onset diabetes?
P
Population
Patients receiving antihypertensive therapy (based on a review of 11 randomized clinical outcome trials and epidemiological studies)
I
Intervention
Antihypertensive medications (thiazide diuretics, beta-blockers, ACE inhibitors, angiotensin II receptor blockers, and calcium channel blockers)
O
Outcome
New-onset diabetes
Different classes of antihypertensive medications have varying effects on the risk of developing new-onset diabetes, highlighting the need to consider metabolic effects when selecting antihypertensive therapy.
Limitations
- Reviewed studies had cardiovascular outcomes rather than incidence of new-onset diabetes as a primary end point
- Difficult to assess the effects of a single class of agents
Cite This Study
George L. Bakris (2006) studied this question.