Angiotensin induces spasms in the isolated guinea pig ileum likely via a post-ganglionic cholinergic mechanism peripheral to the ganglion.
Supports post-ganglionic cholinergic mediation of angiotensin spasm in guinea pig ileum; leaves open relevance to human cardiovascular research.
Atropine and morphine effectively block angiotensin and nicotine-induced spasm on the isolated guinea pig ileum. 2. Mecamylamine, pempidine, pentolinium and hexamethonium blocked nicotine-induced spasms; however, only mecamylamine and pempidine blocked angiotensin spasms, but very high concentrations were required. 3. It is proposed that angiotensin acts on the post-ganglionic cholinergic mechanism of the ileum and that its site of action is probably peripheral to the ganglion.
No takes yet. Share an insight, caveat, or question.
Ross et al. (1960) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: