Histamine in Organs and its Relation to the Sympathetic Nerve Supply.

Summary. Large differences occur in the amount of histamine in various organs of the cow as of the sheep. A certain relation is apparent between the noradrenaline and histamine amounts in an organ and in the corresponding sympathetic nerve in the cow (Table 2). The histamine content of sheep's nerves is considerably lower than that of the corresponding nerves in the cow. The histamine and noradrenaline content of sheep nerves run roughly parallel. No such parallelism is found in organs (Table 3). Sectioning of the sympathetic nerves to various organs in the sheep was followed by a moderate reduction in the histamine content of the spleen but did not alter the histamine amount in the salivary glands or in the kidney.