Gaucher's Disease

In 1882 Ernest Gaucher¹described a form of splenic anemia which he termed "primary idiopathic hypertrophy of the spleen," and which today bears his name. It was not until thirteen years later that Collier²in England, and Picou and Ramond³in France, described the next cases. In 1900, Bovaird⁴reported the first American case. In 1904, Brill and Mandlebaum⁵added the next case to the literature, in which they described for the first time the occurrence of the large characteristic cells in the bone-marrow, and also added much to the knowledge of the pathology of this disease. Schlagenhaufer,⁶in 1907, reported the first case in the German literature. Since then, cases have been reported at regular intervals and with increased frequency. Mandlebaum,⁷in 1919. stated that up to date there were twenty-one authentic cases on record. Ludwig Pick,⁸in 1926, collected thirty-nine