An Illustrated Classification of the Proliferative and Neoplastic Changes in Mouse Bladder Epithelium in Response to Prolonged Iritation

SUMMARY A classification of proliferative and neoplastic lesions of mouse bladder is proposed and illustrated. It differs only slightly from the descriptive account of such lesions given by Bonser and Jull in 1956. I am greatly indebted to my colleagues, Dr J. K. Ball, Dr W. E. H. Field and Mrs M. Walters, who helped to provide the material on which this paper is based, to the staff of the Photographic Department of the Chester Beatty Research Institute for producing the many illustrations, and to Dr C. E. Dukes because of his experience in the “staging” and “grading” of tumours. This investigation has been supported by grants to the Chester Beatty Research Institute (Institute of Cancer Research: Royal Cancer Hospital) from the Medical Research Council, the British Empire Cancer Campaign, the Anna Fuller Fund, and the National Cancer Institute of the National Institutes of Health, U.S. Public Health Service.