An algorithm is developed for identifying optimal focusing conditions in time-of-flight mass spectrometers with certain ionization source geometries. Ions are extracted from the source using time-dependent electric fields. Calculations and experiments demonstrate that use of these optimum conditions can significantly improve mass spectrometer resolution. Matrix-assisted laser desorption/ionization (MALDI) represents an application that is of considerable interest. Because the identification of optimum conditions depends on a correlation between the spatial and velocity distributions of ions in the source region of the instrument, we call this approach space−velocity correlation focusing.
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Colby et al. (1996) studied this question.
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