Population
Spontaneously diabetic and nondiabetic BioBreeding/Worcester (BB/W) rats
Comparison
Dietary sodium deprivation and in vitro… vs Nondiabetic BB/W rats
Design
Preclinical
Authors
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Impaired beta-adrenergic renin secretion in diabetic rats is hypothesis-generating; human studies needed before any clinical relevance.
Spontaneously diabetic rats demonstrate impaired renin secretion in response to beta-adrenergic stimulation despite having increased basal kidney renin content and release.
Cohen et al. (1986) studied this question.
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