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Experimental study reveals increased prM cleavage promotes Japanese encephalitis virus replication while attenuating virulence, highlighting a target for vaccine development.
Japanese encephalitis virus (JEV) is the leading cause of viral encephalitis epidemics in Southeast Asia, affecting mostly children, with high morbidity and mortality. During the viral maturation process, prM is cleaved into M by the cellular endoprotease furin in the acidic secretory system.
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Xiong et al. (2022) studied this question.
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