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If desoxyribonucleic acid, obtained by osmotic shock from T2r^+ bacteriophage, and deproteinized, is treated successively with pancreatic desoxyribonuclease and purified venom phosphodiesterase (1), 62 percent of the phosphorus (P) of the nucleic acid can be recovered in the form of mononucleotides. This result is in distinct contrast to that obtained with calf thymus or wheat germ desoxyribonucleic acid, which are degraded quantitatively to by this procedure (1, 2).
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Robert L. Sinsheimer (1954) studied this question.
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