What question did this study set out to answer?

To design, synthesize, and evaluate novel indole-3-substituted aryl urea derivatives as multitarget antibacterial agents against Xanthomonas oryzae pv. oryzae for bacterial leaf blight management.

August 19, 2026Pest Management Science

Design, synthesis, and multitarget anti‐ Xanthomonas oryzae pv. oryzae mechanism of indole‐3‐substituted aryl urea derivatives

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Authors

MYMengzhi Yang ABAoxuan Bai CLChenchen Li

Discussion

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Overview

Experimental study demonstrates superior antibacterial and greenhouse efficacy of an indole urea derivative against Xanthomonas oryzae, indicating potential as a new rice bactericide.

Key Points

To design, synthesize, and evaluate novel indole-3-substituted aryl urea derivatives as multitarget antibacterial agents against Xanthomonas oryzae pv. oryzae for bacterial leaf blight management.
Synthesized indole-3-substituted aryl urea derivatives and screened their in vitro antibacterial potency, phytotoxicity, and selectivity against Xanthomonas oryzae pv. oryzae (Xoo).
Evaluated curative and preventive greenhouse efficacy on rice crops compared with commercial bactericides thiadiazole copper (TC) and bismerthiazol (BT).
Characterized antibacterial mechanisms through extracellular polymeric substance (EPS) assays, biofilm modulation, ROS-mediated apoptosis detection, and RT-qPCR expression analysis.
Lead compound A29 demonstrated potent in vitro anti-Xoo activity (1.24 μg/mL) alongside low phytotoxicity and high selectivity.
Greenhouse trials showed superior disease control with A29 compared to BT and TC, achieving 51% curative efficacy and 50% preventive efficacy.
Mechanistic profiling confirmed A29 disrupts EPS and biofilm integrity, induces ROS-mediated apoptosis, and regulates key bacterial virulence genes.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a85633c03308d306e2d63d9 https://doi.org/10.1002/ps.71204

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August 19, 2026Pest Management Science

Design, synthesis, and multitarget anti‐ Xanthomonas oryzae pv. oryzae mechanism of indole‐3‐substituted aryl urea derivatives

View Full Paper

Ask AI

Bookmark

Authors

MYMengzhi Yang ABAoxuan Bai CLChenchen Li

Discussion

Member takes

Overview

Experimental study demonstrates superior antibacterial and greenhouse efficacy of an indole urea derivative against Xanthomonas oryzae, indicating potential as a new rice bactericide.

Key Points

To design, synthesize, and evaluate novel indole-3-substituted aryl urea derivatives as multitarget antibacterial agents against Xanthomonas oryzae pv. oryzae for bacterial leaf blight management.
Synthesized indole-3-substituted aryl urea derivatives and screened their in vitro antibacterial potency, phytotoxicity, and selectivity against Xanthomonas oryzae pv. oryzae (Xoo).
Evaluated curative and preventive greenhouse efficacy on rice crops compared with commercial bactericides thiadiazole copper (TC) and bismerthiazol (BT).
Characterized antibacterial mechanisms through extracellular polymeric substance (EPS) assays, biofilm modulation, ROS-mediated apoptosis detection, and RT-qPCR expression analysis.
Lead compound A29 demonstrated potent in vitro anti-Xoo activity (1.24 μg/mL) alongside low phytotoxicity and high selectivity.
Greenhouse trials showed superior disease control with A29 compared to BT and TC, achieving 51% curative efficacy and 50% preventive efficacy.
Mechanistic profiling confirmed A29 disrupts EPS and biofilm integrity, induces ROS-mediated apoptosis, and regulates key bacterial virulence genes.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a85633c03308d306e2d63d9 https://doi.org/10.1002/ps.71204

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