Key result
Elevated 10-year ASCVD risk linked to ~102% higher odds of left ventricular hypertrophy.
Why the study?
The pooled cohort equation for predicting 10-year ASCVD risk has been utilised in Black populations to predict cardiovascular events, but its relationship with left ventricular hypertrophy required exploration.
Is an elevated 10-year ASCVD risk score associated with left ventricular hypertrophy in Nigerian hypertensive patients?
Cross-Sectional (n=934)
No
Is an elevated 10-year ASCVD risk score associated with left ventricular hypertrophy in Nigerian hypertensive patients?
In Nigerian hypertensive patients, an elevated 10-year ASCVD risk score (≥7.5%) is associated with a two-fold increased risk of echocardiographic and ECG left ventricular hypertrophy, suggesting its potential utility for guiding LVH screening in resource-limited settings.
Hypothesis-generating for PCE-LVH association in African hypertensives; prospective validation needed before clinical use.
Background: The pooled cohort equation (PCE) for predicting the 10-year risk of atherosclerotic cardiovascular disease (ASCVD) has been utilised in Black populations to predict cardiovascular events. Objective: We explored the relationship between PCE ASCVD risk and left ventricular hypertrophy (LVH). Materials and Methods: A total of 934 hypertensives from the Federal Medical Centre Abuja Hypertension Registry were analysed for this study. The participants were divided into two groups: those with low ASCVD risk (<7.5%) and those with elevated ASCVD risk (≥7.5%). Electrocardiographic (ECG) LVH was defined by the presence of any of Sokolow-Lyon, Cornell voltage or Gubner-Ungerleider criteria. Echocardiographic LVH was defined as an elevated LV mass index using the linear cube formula of the American College of Cardiology. Results: Participants with elevated ASCVD risk were older (59.2 ± 9.0 years) than those with low ASCVD risk ( P < 0.001). Among participants with elevated ASCVD risk, 299 (42.1%) and 181 (26.3%) had echocardiographic and ECG LVH compared with 75 (32.3%) and 44 (19.6%) in those with low ASCVD risk, respectively ( P < 0.05). Those with elevated ASCVD risk had higher odds of having echocardiographic (odds ratio [OR]: 2.02, 95% confidence interval CI 1.39–2.93) and ECG LVH (OR: 2.00, 95% CI 1.29–3.08) compared to those in the low-risk group ( P < 0.05). Conclusion: In this study, an elevated 10-year ASCVD risk was associated with a two-fold increase in the risk of echocardiographic and ECG LVH in a population of Nigerian hypertensives. In resource-limited settings, the use of the ASCVD risk score may facilitate timely referrals for the diagnosis and management of LVH.
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Abiodun et al. (2026) conducted a cross-sectional in Hypertension (n=934). Elevated 10-year ASCVD risk (≥7.5%) vs. Low ASCVD risk (<7.5%) was evaluated on Echocardiographic left ventricular hypertrophy (OR 2.02, 95% CI 1.39-2.93, p=<0.05). Elevated 10-year ASCVD risk (≥7.5%) was associated with significantly higher odds of echocardiographic left ventricular hypertrophy compared to low risk (OR 2.02; 95% CI 1.39-2.93; P<0.05).
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