Serum periostin levels in myocardial infarction: Findings from forensic autopsy cases

Figures

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  Fig 1. Representative findings of AMI used for diagnostic criteria and sampling. (A) Horizontal cross-section of AMI case showing five myocardial regions (LVAW, LVLW, IVS, RVW) outlined, and LCx with a coronary thrombus identified and sampled. (B) Histological features of early ischemic injury, including wavy myocardial fibers without inflammatory infiltration, interstitial edema, and hemorrhage (H&E stain). (C) Advanced ischemic injury with extensive neutrophilic infiltration (H&E stain). (D) Coronary artery thrombus in LCx (EVG stain). (E) Example of myocardium without fibrotic scarring, evaluated by EVG stain for re-MI assessment. AMI, acute myocardial infarction; LAD, left anterior descending artery; LCx, left circumflex artery; RCA, right coronary artery; LVAW, anterior wall of the left ventricle; LVLW, lateral wall of the left ventricle; LVPW, posterior wall of the left ventricle; IVS, interventricular septum; RVW, right ventricular wall; H&E, Hematoxylin and eosin; EVG, Elastic Van Gieson; re-MI, recurrent myocardial infarction.

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  Fig 2. (A) Scatter plot illustrating the serum periostin levels in subjects with AMI, asthma, and trauma (n = 80). Based on this comparison, the trauma group serves as a reference for the AMI and asthma groups. (B) In the trauma groups, correlation analysis revealed no significant association between serum periostin levels and PM interval (r = −0.058, p = 0.82). AMI, acute myocardial infarction. PM interval, post-mortem interval.

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  Fig 3. Comparison of serum periostin levels among AMI, asthma, and trauma groups. One-way analysis of variance (ANOVA) with Bonferroni adjustment revealed highly significant contrasts between AMI and asthma (p = 0.03015) and between AMI and trauma (p = 0.00048) groups. No significant difference was observed between asthma and trauma groups (p = 0.98659). AMI, acute myocardial infarction.

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  Fig 4. Correlation analysis between serum periostin levels and physical parameters, including age (r = 0.128, p = 0.398), BMI (r = –0.0581, p = 0.701), and HW (r = –0.0793, p = 0.6). BMI, body mass index; HW, heart weight.

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  Fig 5. ROC curve analysis of serum periostin measurements for the diagnosis of AMI with a cut-off value of 556 ng/mL. The sensitivity was 93.8%, and the specificity was 67.4%, with an AUC of 0.814 (95% CI: 0.708–0.920). ROC, receiver operating characteristic; AUC, area under the curve; CI, confidence interval.