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August 19, 2026British Journal of Ophthalmology

Topographic analysis of choroidal thickness in pachychoroid disease using ultra-widefield swept-source optical coherence tomography

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Authors

AQAlberto QuartaUniversity of California, Los Angeles CSCeren SoyluUniversity of California, Los Angeles RARouzbeh AbbasgholizadehUniversity of California, Los Angeles

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Implication

Observational imaging study reveals diffuse choroidal thickening beyond the fovea in pachychoroid disease, indicating widespread choroidal remodeling as an imaging biomarker.

Key Points

To characterize regional and topographic choroidal thickness profiles using ultra-widefield swept-source optical coherence tomography and compare normal eyes with eyes affected by pachychoroid disease.
Assessed 60 participants (24 with pachychoroid disease and 36 normal controls) using ultra-widefield swept-source optical coherence tomography with a 26 mm × 21 mm field of view centered on the fovea.
Quantified choroidal thickness within concentric rings and sectors centered on the optic nerve head using linear mixed-effects models adjusted for age, sex, and spherical equivalent.
Pachychoroid eyes demonstrated significantly greater choroidal thickness across all sectors and eccentricities compared with normal eyes (p<0.001), with the largest thickness differences detected in the temporal sector.
Pachychoroid status was an independent predictor of increased choroidal thickness in all sectors (p<0.05) after adjusting for age, sex, and spherical equivalent, while spherical equivalent independently correlated with thickness in inferior, superior, and temporal sectors.

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Quarta et al. (2026) studied this question.

synapsesocial.com/papers/6a85637603308d306e2d695c https://doi.org/10.1136/bjo-2026-329844

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Implication

Observational imaging study reveals diffuse choroidal thickening beyond the fovea in pachychoroid disease, indicating widespread choroidal remodeling as an imaging biomarker.

Topographic analysis of choroidal thickness in pachychoroid disease using ultra-widefield swept-source optical coherence tomography

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Implication

Key Points

Cite This Study

Topographic analysis of choroidal thickness in pachychoroid disease using ultra-widefield swept-source optical coherence tomography

Discussion

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Implication

Key Points

Cite This Study

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