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August 19, 2026Middle East Current PsychiatryOpen Access

Cognitive and psychiatric outcomes of methamphetamine (Shabu Drug) abstinence: a 6-months longitudinal study in Tanta, Egypt

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Authors

AAAbdelrahman Abdelhakim AssafMSMai Ahmed Salem

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Overview

Longitudinal study demonstrates significant reductions in depression, anxiety, and cognitive deficits in abstinent methamphetamine users, indicating potential neuropsychiatric recovery with cessation.

Key Points

  • To assess longitudinal changes in cognitive performance, anxiety, depression, and suicidality among methamphetamine users across six months of abstinence.
  • Prospective longitudinal study conducted in inpatient and outpatient neurology and psychiatry settings in Egypt with 30 current or recent methamphetamine users assessed at baseline, 3 months, and 6 months of abstinence.
  • Evaluated psychiatric symptoms using the Beck Depression Inventory-II (BDI-II), Generalized Anxiety Disorder-7 (GAD-7), and Beck Scale for Suicidal Ideation (BSSI).
  • Assessed cognitive domains (attention, naming, visuospatial/executive function, language, memory, abstract ability, and orientation) using the Montreal Cognitive Assessment (MoCA).
  • Depression, anxiety, and suicidality scores significantly declined from baseline to 3 months and showed further significant reductions at 6 months of abstinence (P < 0.05 for all comparisons).
  • Total MoCA cognitive scores, as well as attention, naming, and visuospatial/executive subscales, improved significantly at 3 months and 6 months compared to baseline, with additional gains between 3 and 6 months (P < 0.05).
  • Language and delayed recall subscale scores improved significantly by 3 months (P < 0.05) with no further change at 6 months, while abstract ability showed significant improvement specifically at 6 months (P < 0.05).

Cite This Study

Assaf et al. (2026) studied this question.

synapsesocial.com/papers/6a85637603308d306e2d69a5https://doi.org/10.1186/s43045-026-00665-8
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