Key result
Repeat mechanical thrombectomy achieves successful recanalization in recurrent large vessel occlusion with deferred anticoagulation.
Why the study?
Anticoagulation decisions are particularly challenging when hemorrhagic transformation occurs after reperfusion therapy in AF-related cardioembolic stroke, balancing recurrent ischemic risk against intracranial bleeding progression.
Case Report (n=1)
This case demonstrates that repeat mechanical thrombectomy can be an effective treatment for recurrent large vessel occlusion when anticoagulation must be deferred.
May support repeat thrombectomy feasibility when anticoagulation is deferred post-hemorrhagic transformation; hypothesis-generating and requires prospective validation.
Atrial fibrillation (AF) is a major cause of cardioembolic stroke, and decisions regarding anticoagulation become particularly challenging when hemorrhagic transformation occurs after reperfusion therapy. We report the case of a 76-year-old man who presented with an acute left middle cerebral artery (MCA) occlusion and underwent intravenous thrombolysis followed by successful mechanical thrombectomy. Subsequent imaging demonstrated hemorrhagic transformation of the infarcted area, and newly diagnosed AF was identified as the likely embolic source. Anticoagulation was deferred because of concerns regarding intracranial bleeding. One week later, the patient developed recurrent neurological deficits secondary to a new ipsilateral large vessel occlusion, requiring repeat mechanical thrombectomy. Following radiological stabilization of the hemorrhagic transformation, anticoagulation was initiated without further complications. This case highlights the clinical challenge of balancing the risk of recurrent cardioembolic event against the risk of hemorrhagic progression when determining the timing of anticoagulation after AF-related ischemic stroke. It also demonstrates that repeat mechanical thrombectomy can be an effective treatment option for selected patients with recurrent large vessel occlusion.
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Elnour et al. (2026) conducted a case report in Atrial fibrillation-related ischemic stroke with hemorrhagic transformation (n=1). Repeat mechanical thrombectomy was evaluated. Repeat mechanical thrombectomy successfully recanalized a recurrent large vessel occlusion in a patient with newly diagnosed atrial fibrillation whose anticoagulation was deferred due to hemorrhagic transformation.
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