What question did this study set out to answer?

To evaluate plasma vitamin C concentrations in patients with sepsis and septic shock and assess the clinical impact of high-dose intravenous vitamin C on organ dysfunction, inflammation, and mortality.

August 19, 2026The Egyptian Journal of Critical Care MedicineOpen Access

Vitamin C deficiency and its effect as adjuvant therapy in sepsis patients

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Authors

EAEslam Abdelhady MSMohammed Ashraf Shawky MNMahmoud Nour

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Overview

Interventional cohort study demonstrates reduced organ dysfunction and vasopressor requirements with intravenous vitamin C in sepsis, indicating clinical benefits for deficient patients.

Key Points

To evaluate plasma vitamin C concentrations in patients with sepsis and septic shock and assess the clinical impact of high-dose intravenous vitamin C on organ dysfunction, inflammation, and mortality.
Conducted a prospective, interventional, non-randomized controlled cohort study of 100 adult ICU patients with sepsis or septic shock at Cairo University Hospitals between December 2019 and September 2021.
Administered intravenous vitamin C (6 g/day for 4 days; n = 75) or placebo (n = 25) alongside standard sepsis management.
Measured plasma vitamin C, C-reactive protein, SOFA scores, vasopressor requirements, mechanical ventilation use, ICU length of stay, and mortality.
Vitamin C administration significantly reduced SOFA scores at day 4 (5.5 ± 3.1 vs. 9.2 ± 4.2, p = 0.049) and day 6 (3.3 ± 2.5 vs. 8.1 ± 4.1, p = 0.002).
High-dose therapy achieved normal plasma vitamin C levels (> 70 µmol/L) in 50.7% vs. 8.0% of patients by day 4 (p < 0.001), reduced C-reactive protein (p < 0.001), and decreased vasopressor requirements on day 1 (p = 0.026) and day 4 (p = 0.05).
No statistically significant differences occurred between groups in mean arterial pressure, mechanical ventilation, renal replacement therapy, ICU duration, or mortality.

Cite This Study

Abdelhady et al. (2026) studied this question.

synapsesocial.com/papers/6a8563ae03308d306e2d6f8a https://doi.org/10.1007/s44349-026-00059-z

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August 19, 2026The Egyptian Journal of Critical Care MedicineOpen Access

Vitamin C deficiency and its effect as adjuvant therapy in sepsis patients

View Full Paper

Ask AI

Bookmark

Authors

EAEslam Abdelhady MSMohammed Ashraf Shawky MNMahmoud Nour

Discussion

Member takes

Overview

Interventional cohort study demonstrates reduced organ dysfunction and vasopressor requirements with intravenous vitamin C in sepsis, indicating clinical benefits for deficient patients.

Key Points

To evaluate plasma vitamin C concentrations in patients with sepsis and septic shock and assess the clinical impact of high-dose intravenous vitamin C on organ dysfunction, inflammation, and mortality.
Conducted a prospective, interventional, non-randomized controlled cohort study of 100 adult ICU patients with sepsis or septic shock at Cairo University Hospitals between December 2019 and September 2021.
Administered intravenous vitamin C (6 g/day for 4 days; n = 75) or placebo (n = 25) alongside standard sepsis management.
Measured plasma vitamin C, C-reactive protein, SOFA scores, vasopressor requirements, mechanical ventilation use, ICU length of stay, and mortality.
Vitamin C administration significantly reduced SOFA scores at day 4 (5.5 ± 3.1 vs. 9.2 ± 4.2, p = 0.049) and day 6 (3.3 ± 2.5 vs. 8.1 ± 4.1, p = 0.002).
High-dose therapy achieved normal plasma vitamin C levels (> 70 µmol/L) in 50.7% vs. 8.0% of patients by day 4 (p < 0.001), reduced C-reactive protein (p < 0.001), and decreased vasopressor requirements on day 1 (p = 0.026) and day 4 (p = 0.05).
No statistically significant differences occurred between groups in mean arterial pressure, mechanical ventilation, renal replacement therapy, ICU duration, or mortality.

Cite This Study

Abdelhady et al. (2026) studied this question.

synapsesocial.com/papers/6a8563ae03308d306e2d6f8a https://doi.org/10.1007/s44349-026-00059-z

View Full Paper

Ask AI

Bookmark