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November 28, 2025Food Science & NutritionOpen Access

Vitamin C Supplementation During Intensive Care Unit Stay Is Associated With Improved Outcomes in Critically Ill Patients With Sepsis‐Induced Coagulopathy: A Cohort Study

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Authors

JLJi LiFLFulin LiDLDan Luo

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Overview

Cohort study shows vitamin C decreases 28-day mortality in critically ill patients, indicating better survival outcomes.

Key Points

  • Vitamin C supplementation reduced 28-day all-cause mortality by 48% in critically ill patients, while overall ICU mortality decreased significantly.
  • Analysis involved 18,283 patients in the unmatched cohort and 2,251 in the matched cohort using propensity score matching and Cox models.
  • Continuous vitamin C use for over 6 days was linked with improved in-hospital outcomes, affirmed by sensitivity analyses in the unmatched cohort.
  • Findings highlight potential for vitamin C to reduce mortality rates, but further high-quality studies are necessary for conclusive validation.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/6928f11ba65b730b9ea7a24chttps://doi.org/10.1002/fsn3.71263
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Vitamin C Supplementation During Intensive Care Unit Stay Is Associated With Improved Outcomes in Critically Ill Patients With Sepsis‐Induced Coagulopathy: A Cohort Study2025 · 1 citations
  2. 2Vitamin C deficiency and its effect as adjuvant therapy in sepsis patients2026
  3. 3Intravenous Vitamin C as an Add-on Therapy for the Treatment of Sepsis in an Intensive Care Unit: A Prospective Cohort Study2024 · 3 citations
  4. 4Impact of Vitamin D3 Supplementation on 28-Day ICU Mortality in Sepsis Patients: A Retrospective Study with Propensity Score Matching2026
  5. 5Clinical Efficacy of Megadose Vitamin C in Sepsis: Protocol for a Multicenter Randomized Single-Blind Placebo-Controlled Clinical Trial2024 · 1 citations