Comparison of a Computable Pediatric Sepsis Phenotype Tool in Argentinian and U.S. Cohorts

Rebecca I. Caldino Bohn; María E Galván; Vanessa S. Lanziotti; Kate F. Kernan; C. Viqueira Guzmán; Juan Carlos Vassallo; J A Carcillo; Luis Landry; Hyun-Jung Park; Silvina Ruvinsky; S. Santos; Roberto Jabornisky; on behalf of the Members of Argentinian ESSPED2 (Estudio Sepsis y Shock Séptico Pediátrico 2) Registry and the Phenotyping Pediatric Sepsis-Induced Multiple Organ Failure U.S. study

doi:10.1097/pcc.0000000000004023

August 17, 2026Pediatric Critical Care Medicine

Comparison of a Computable Pediatric Sepsis Phenotype Tool in Argentinian and U.S. Cohorts

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Key Points

To evaluate whether a computable pediatric sepsis phenotype tool derived in the United States can reliably identify clinical phenotypes and predict outcomes in an independent Argentinian cohort.
Retrospective cohort study comparing 99 pediatric sepsis patients (aged 1 month to 18 years) across 51 Argentinian PICUs (2021) and 404 patients (aged 44 gestational weeks to 18 years) across 9 U.S. PICUs (2015–2017).
Assigned patients to four sepsis phenotypes (PedSep A, B, C, D) using a 25-variable bedside computable tool at 24 hours to analyze mortality, heterogeneity of treatment response, and trial power requirements.
Overall mortality was significantly higher in the Argentinian cohort than the U.S. cohort (20.2% [20/99] vs. 11.14% [45/404], p = 0.025).
Mortality was highest in the PedSep D phenotype across both groups, with no significant difference between cohorts (32.14% [9/28] in Argentina vs. 33.93% [19/56] in the U.S., p = 1.0).
Heterogeneity of treatment response to anti-inflammatory therapies was observed in PedSep D compared with PedSep A, B, and C (p < 0.05), indicating a requirement of 55 PedSep D patients per arm in future trials.

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Implication

Retrospective cohort study reveals consistent identification of high-risk hyperinflammatory phenotypes in pediatric sepsis across international cohorts, indicating feasibility for targeted trials.

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Cite This Study

Bohn et al. (2026) studied this question.

synapsesocial.com/papers/6a8563ae03308d306e2d70b2 https://doi.org/10.1097/pcc.0000000000004023

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Comparison of a Computable Pediatric Sepsis Phenotype Tool in Argentinian and U.S. Cohorts

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Comparison of a Computable Pediatric Sepsis Phenotype Tool in Argentinian and U.S. Cohorts

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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