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August 19, 2026Journal of Drug Delivery and TherapeuticsOpen Access

Antifungal Activity of the Ethanol Extract of Terminalia laxiflora Engl. (Combretaceae) from the Eastern Logone Province of Chad

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Authors

BMBégoto MbailassemIBIssakou Bakarnga‐ViaRARoberto Alladoum

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Overview

In vitro study reveals broad-spectrum antifungal inhibition by Terminalia laxiflora extracts against pathogenic fungal strains, suggesting its potential as a natural therapeutic source.

Key Points

  • To evaluate the in vitro antifungal activity and phytochemical composition of ethanolic bark and root extracts from Terminalia laxiflora against pathogenic filamentous fungi.
  • Extracted bioactive compounds from Terminalia laxiflora bark and roots collected in Chad using ethanol maceration.
  • Assessed antifungal efficacy against Aspergillus flavus, Aspergillus niger, Trichophyton rubrum, Trichophyton soudanense, and Microsporum canis using the agar incorporation method to determine MIC and MFC.
  • Performed qualitative phytochemical screening to identify key classes of secondary metabolites.
  • Ethanol extraction yields ranged from 9.89% to 18.37% across plant parts.
  • Phytochemical screening identified flavonoids, gallic tannins, saponins, alkaloids, heterosides, free quinones, anthraquinones, sterols, terpenoids, and anthocyanins.
  • Extracts inhibited the growth of all five tested fungal species, with minimum inhibitory concentrations (MIC) ranging from 1 mg/mL to 3 mg/mL.

Cite This Study

Mbailassem et al. (2026) studied this question.

synapsesocial.com/papers/6a8563c403308d306e2d7143https://doi.org/10.22270/jddt.v16i8.7949
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