Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 19, 2026AntioxidantsOpen Access

The Use of Curcumin to Target Oxidative Stress and Inflammation in Type 2 Diabetes Mellitus and Its Complications: Molecular Mechanisms and Therapeutic Perspectives

View Full Paper
Ask AI
Bookmark
Share

Authors

JZJia ZhangQSQi-Peng ShuYTYuntao Tang

Discussion

Loading...

Member takes

Overview

Review demonstrates curcumin attenuates oxidative stress and inflammatory biomarkers in type 2 diabetes, suggesting its potential role as an adjunctive metabolic therapy.

Key Points

  • To review the molecular mechanisms, clinical evidence, and translational challenges of curcumin as an adjunctive therapeutic strategy for targeting oxidative stress and inflammation in type 2 diabetes mellitus.
  • Synthesized molecular and biological pathways involving curcumin's impact on reactive oxygen species generation, cellular antioxidant defenses, and inflammatory cascades in metabolic disease.
  • Evaluated clinical trial evidence, pharmacokinetic profiles, formulation bioavailability barriers, and safety considerations in diabetes management.
  • Curcumin activates Nrf2/ARE signaling, inhibits NF-κB and MAPK/JNK cascades, and suppresses NADPH oxidase activity, resulting in lower pro-inflammatory cytokines and reduced C-reactive protein levels.
  • Clinical evidence indicates modest improvements in glycemic, oxidative, and inflammatory biomarkers, though therapeutic translation remains limited by low bioavailability and a lack of definitive long-term outcome data.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6a8563d703308d306e2d7346https://doi.org/10.3390/antiox15081025
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Curcumin, an active component of turmeric: biological activities, nutritional aspects, immunological, bioavailability, and human health benefits - a comprehensive review2025 · 112 citations
  2. 2Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers1998 · 1,970 citations
  3. 3Curcumin protects islet beta cells from streptozotocin‑induced type 2 diabetes mellitus injury via its antioxidative effects2022 · 18 citations
  4. 4The effects of curcumin supplementation on high‐sensitivity C‐reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: A randomized, double‐blind, placebo‐controlled trial2019 · 186 citations
  5. 5Curcumin improves glycolipid metabolism through regulating peroxisome proliferator activated receptor γ signalling pathway in high-fat diet-induced obese mice and 3T3-L1 adipocytes2017 · 50 citations