March 9, 2014Nature Cell BiologyOpen Access

Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

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Population

Preclinical model investigating the developmental origins of white adipose tissue (WAT)

Comparison

Lineage tracing of Wt1-expressing cells vs Subcutaneous WAT and brown adipose tissue

Design

Preclinical

Authors

YCYou-Ying ChauThe Queen's Medical Research Institute RBRoberto BandieraUniversity of Cambridge ASAlan SerrelsUniversity of Edinburgh

Discussion

Member takes

Implication

Should not alter clinical fat depot assessment; leaves open translational relevance of Wt1+ mesothelial progenitors to human visceral adiposity.

Structured PICO

Population

Preclinical model investigating the developmental origins of white adipose tissue (WAT)

Intervention

Lineage tracing of Wt1-expressing cells

Comparator

Subcutaneous WAT and brown adipose tissue

Outcome

Contribution of Wt1-expressing cells to adipocytes in different fat depotssurrogate

This study reveals a major ontogenetic difference between visceral and subcutaneous white adipose tissue, identifying the lateral plate mesoderm and mesothelium as a major source of visceral adipocytes.

Cite This Study

Chau et al. (2014) studied this question.

synapsesocial.com/papers/6a8563e0734852141cd4cb62 https://doi.org/10.1038/ncb2922

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Implication

Should not alter clinical fat depot assessment; leaves open translational relevance of Wt1+ mesothelial progenitors to human visceral adiposity.

Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider